Frontiers in Cardiovascular Medicine

ObjectiveTo investigate the correlation between clinical characteristics and cardiac injury of COVID-2019 pneumonia. MethodsIn this retrospective, single-center study, 41 consecutive corona virus disease 2019 (COVID-2019) patients (including 2 deaths) of COVID-2019 in Beijing Youan Hospital, China Jan 21 to Feb 03, 2020, were involved in this study. The high risk factors of cardiac injury in different COVID-2019 patients were analyzed. Computed tomographic (CT) imaging of epicardial adipose tis...

RationaleCoronavirus disease 2019 (COVID-19) can cause a viral pneumonia together with other extrapulmonary complications. Acute cardiac related injury (ACRI) is common in hospitalized COVID-19 patients. ObjectiveTo explain the pathological mechanism of ACRI and improve the treatment strategy by retrospectively observing the factors associated with ACRI and factors affecting the prognosis of ACRI with COVID-19 at an early stage. Methods619 COVID-19 patients were from Tongji Hospital, Wuhan. St...

BACKGROUNDSmall extracellular vesicles (sEVs) released in the cardiac microenvironment are reported to regulate cardiac remodelling, partially via microRNA transfer. Harvesting sEVs produced exclusively from the myocardium remains challenging and a solid research platform for sEV cardiovascular testing needs to be established. Organotypic living myocardial slices (LMS) allow to mimic cardiac disease and to record electrophysiological responses to biological and pharmacological stimuli. This stud...

BackgroundThe triglyceride glucose (TyG) index serves as a surrogate indicator of insulin resistance. However, there is limited evidence on the association between the TyG index and heart failure with preserved ejection fraction (HFpEF) in patients with coronary heart disease (CHD). MethodsThe 62,794 CHD patients were included used to analyze the relationship between the TyG index and heart failure (HF) in CHD patients. Of these, 8,606 patients who underwent echocardiography were included to id...

BACKGROUNDA key problem for results of coronary artery bypass grafting (CABG) is different long-term patency of grafts (internal mammary artery [IMA], radial artery [RA], and saphenous vein [SV]). METHODS AND RESULTSWe investigated the biological differences among IMA-SV, RA-SV, and IMA-RA using multi-omics approaches in order to explore new therapeutic targets. Trios of the human IMA, RA, and SV (n=72) from the CABG patients were studied using transcriptomics and proteomics. Differential mRNAs...

BackgroundIncreased postoperative glycemic variability (GV) has been shown to be associated with an increased risk for adverse outcomes. However, the impact of postoperative GV on the long-term mortality after cardiac surgery, particularly with regarding other associated interactive factors, remains unknown. In this study, we sought to investigate whether postoperative GV is associated with one-year mortality, and to determine whether preoperative hemoglobin A1C (HbA1C) levels or diabetes status...

BackgroundCardiomyocytes increase DNA content in response to stress in humans. Proliferation has been reported in cardiomyocytes in failing hearts and following LVAD unloading which may represent a resolution of this process through cell division. However, cardiac recovery from LVAD is rare. MethodsWe quantified cardiomyocyte nuclear number, cell size, DNA content and the frequency of cell cycling markers by imaging flow cytometry from human subjects undergoing LVAD implantation or primary tran...

Background and AimsSome, but not all, patients with heart failure (HF) develop pulmonary vascular disease (PVD), which contributes to poor prognosis. Mechanisms leading to PVD in HF are poorly understood. Unbiased analysis of transpulmonary gradients may identify mediators of PVD by finding proteins consumed or elaborated across the lungs. Methods21 controls and 160 HFrEF patients underwent pulmonary artery (PA) catheterization with blood sampling from postcapillary (wedged balloon) and precapi...

BackgroundLeft ventricular ejection fraction (LVEF) measurements by echocardiography are subject to problems such as low interobserver reproducibility, which depends on the skill of the observer, and variations in measurement technique. ObjectiveWe investigated the reproducibility of echocardiography by comparing the measurement results of a certified sonographer with those of control students. MethodsA total of 30 subjects, 22 adult students and 8 staff members of Shubun University, were incl...

BackgroundCell-free eosinophil granules, which are considered harmful to the heart, are stained red by haematoxylin-eosin (HE); however, they can be overlooked in cardiac tissue due to the reddish staining of cardiomyocytes and fibres. Direct fast scarlet (DFS) and Congo red (CR), known for staining amyloid deposits, stain eosinophil granules; however, no firm evidence currently exists. This study aimed to confirm that DFS and CR stain eosinophil granules red and evaluate their advantages over H...

BackgroundAfter myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function. These alterations are believed to be linked to endoplasmic reticulum (ER) stress, though the specific mechanisms are not fully understood. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. ResultsExcessive oxidative stress was activated in humans post-myo...

ObjectiveAortic clamping time during cardiopulmonary bypass (CPB) has been associated with inflammatory processes such as systemic inflammatory response syndrome. In this study, we evaluated the association of CPB and aortic cross-clamping (ACC) times with systemic inflammatory response index (SIRI) and systemic immune inflammation index (SIII) in isolated coronary artery bypass surgery (CABG). Methods96 patients who underwent isolated CABG at a single center between 2021 and 2023 were retrospe...

ObjectiveThe objective of this study is to look into how TGF-beta and Angiotensin II disrupt cardiogenic regulators (Isl1, Brg1/Baf60-Smarcd3 complex, Nkx2-5, GATA4, Tbx5, Mef2c, HAND1/2, MYOCD, MSX2, HOPX, Wnt-signaling pathway, Notch, FGF, BMPs) during cardiac remodeling post-ischemic injury. BackgroundCardiac remodeling post-ischemic injury, influenced by TGF-beta and Angiotensin II, disrupts critical cardiogenic regulators essential for heart function. Understanding these disruptions is cru...

BackgroundFever is a common clinical manifestation following acute myocardial infarction(AMI). However, differentiating its etiology-specifically, distinguishing between fever caused by the absorption of necrotic tissue and fever due to concurrent infection is critical, as this distinction directly influences treatment decisions and patient prognosis. MethodsThis retrospective study reviewed AMI patients from two centers. Participants were divided into two groups: a fever of non-infectious orig...

BackgroundThe clinical significance of ST-segment depression (STD) on electrocardiogram (ECG) in resting patients without prior cardiac disease and symptoms of angina pectoris in unclear. This study was aimed to elucidate this problem. MethodsPatients with non-anginal chest pain or those who underwent ECG screening were enrolled. Echocardiography (Echo) and resting and stress ECG were performed.; stress ECG was recorded during exercise and recovery period. For stress ECG, ST-segment/heart-rate ...

AbstractO_ST_ABSBackgroundC_ST_ABSCoronary artery disease is a significant health concern and can lead to death. Coronary artery bypass grafting (CABG) is the primary surgical treatment for this disease. However, the long-standing hypothesis that women face higher surgical mortality than men after CABG remains controversial. The universal healthcare system and the established national cardiovascular surgery registry of Japan provide a unique oppotunity to assess this supposition. This study aime...

BackgroundChemokine C-C motif ligand (CCL)21 and CCL19 are well-recognized to associate with adverse events of cardiovascular disease, especially long-term prognosis. However, few studies have reported its correlation with heart failure. PurposeTo investigate and compare the predictive value of CCL21 and CCL19 serum levels in patients with heart failure. MethodsIn this prospective, observational, single-center study, 221 patients with heart failure and 55 healthy controls were included. ROC cu...

PurposeTo establish a nomogram for predicting the overall survival (OS) of patients with ischemic cardiomyopathy and heart failure based on the Surgical Treatment for Ischemic Heart Failure (STICH) trail. MethodsPatients who had valid key variables in the hypothesis 1 were included and randomly divided into the training and validation groups (7:3 ratio). Using Cox proportional hazards model, predictors for the OS in training group were identified and integrated to establish a nomogram for predi...

BACKGROUNDRnd3, a small Rho-GTPase, is involved in various cardiovascular diseases, but its role in diabetes-induced cardiomyocyte senescence is unclear. This study aims to investigate the role of Rnd3 in cardiomyocyte senescence in diabetes cardiomyopathy (DCM). METHODSRnd3 expression was assessed in human tissue using qPCR, and its correlation with clinical parameters was analyzed. Rnd3 and Senescence-associated secretory phenotype (SASP)-related marker expression was determined in heart tiss...

BackgroundSince the emergence of the SARS COV-19 pandemic, multiple extrapulmonary manifestations of the virus have been reported from around the world. Cardiovascular complications including arrhythmias in patients with COVID-19 have been described in multiple studies. Our aim was to review various case reports detailing the new onset of heart block in COVID-19 patients and to summarise the clinical course of these patients. MethodsWe systematically reviewed all reports published and indexed i...